5-MTHF

• Contributes to the maintenance of good health
• Helps the body to metabolize proteins
• Helps in the formation of red blood cells
• Helps prevent folate deficiency

Description

Generically known as folate, 5-methyltetrahydrofolate (5-MTHF) is the most biologically active form of the water-soluble B vitamin, folic acid. It is the form into which the body must convert all other forms of folic acid before it can be used. With vitamin B12, 5-MTHF serves as a methyl group donor. The body uses methyl groups in many nervous system and metabolic processes, including the conversion of homocysteine to methionine, the synthesis of monoamine neurotransmitters (serotonin, dopamine, epinephrine), the production of melatonin, and DNA synthesis. In addition, sufficient folate is necessary for brain and nervous system functions. Insufficient folate intake is likely to occur in a diet consisting primarily of processed and/or cooked foods, as processing or cooking destroys the vitamin. In addition to inadequate dietary intake, poor absorption or misuse can lead to folate depletion, as can excessive alcohol consumption and other factors.

Despite research showing that folic acid and 5-MTHF have equivalent bioavailability and that supplementation with high doses of folic acid can "force" its conversion to a more active form, 5-MTHF is often the preferred form to replenish folate. This is primarily due to the inadequacy of folic acid to raise plasma levels when certain conditions are present. In this formula, 5-MTHF is provided in the form of Quatrefolic®, the glucosamine salt of 5-MTHF. Quatrefolic has been shown to have greater stability, solubility and bioavailability than the calcium salt forms of 5-MTHF. Folate is stored in red blood cells, where levels were found to be higher after 5-MTHF supplementation compared to folic acid and placebo. For example, patients who received 5 mg of 5-MTHF had 700% higher plasma levels than patients who received folic acid.

Good folate status is associated with a healthy mood. 5-MTHF may improve trimonoamine neurotransmitter synthesis and help maintain a sense of calm and a healthy attitude. In non-smoking adults, higher folate levels indicate gingival tissue strength, and a range of vitamins, including folate, appear to act in support of oral health mechanisms.

Folate intake is particularly important for women of childbearing age. Studies indicate that supplementation during pregnancy promotes a healthy outcome. In a 2010 study, researchers concluded that if a woman had certain genetic variations during pregnancy, it would lead to reduced methylation capacity and subsequent hypomethylation of DNA.

Dosage

Adults: Take 1 capsule per day.

Nutritional informations

Medicinal ingredients (per capsule): Folate ((6s)-5-Methyltetrahydrofolic acid, glucosamine salt, synthetic) ...... 1000 mcg

Non-medicinal ingredients: Hypromellose, magnesium stearate, microcrystalline cellulose, silicon dioxide, stearic acid.

/TABS

Adultes : Prendre 1 capsule par jour.