B Activ

• Vitamin supplement.
• A factor in the maintenance of good health.
• Helps the body to metabolize carbohydrates, fats and proteins.
• Aids in normal growth and development.
• Helps in the formation of tissues.
• Helps in the formation of red blood cells.
• Helps support liver function.
• Helps prevent folate deficiency in men and women who are not pregnant or nursing.

Description

Water-soluble B vitamins must be absorbed in the small intestine and then travel to the liver where they are biotransformed into their active coenzyme forms. B Activ contains vitamins B1 (thiamine), B2 (riboflavin), B6 (pyridoxine) and B12 (methylcobalamin) in their physiologically active form, making them easier to absorb and "ready to use". For example, in patients receiving pyridoxine hydrochloride, only 33% responded with an increase in plasma pyridoxal-5'-phosphate (P5P); however, the level increased in all patients receiving P5P.

Folate is supplied in the form of 5-methyltetrahydrofolate (5-MTHF), which bypasses the metabolic steps of folate bioactivity. Despite research showing that folic acid and 5-MTHF have equivalent bioavailability and that supplementation with high doses of folic acid can "force" its conversion to a more active form, 5-MTHF, may be the preferred form to replenish folate. This may be particularly applicable to people with digestive problems or genetic variations in folate metabolism. In this formulation, 5-MTHF is provided as Quatrefolic, the glucosamine salt of 5-MTHF. In vitro and in vivo studies have shown that Quatrefolic has greater stability, solubility and bioavailability than the calcium salt forms of 5-MTHF. Folate is stored in small amounts in red blood cells (RBCs), and RBC folate has been shown to be higher after 5-MTHF supplementation compared to folic acid and placebo. Similarly, patients who received 5 mg of 5-MTHF had 700% higher plasma 5-MTHF levels than patients who received folic acid.

Another unique ingredient in this formula is benfotiamine (S-benzoylthiamine O-monophosphate), a safe, fat-soluble analog of thiamine. One study showed that it not only increased blood and tissue levels of thiamine at least five times more than the water-soluble salt, but also remained bioavailable after oral administration up to 3.6 times longer than the thiamine salt.6 Benfotiamine is the most potent of a class of thiamine-derived compounds found in small amounts in members of the Allium genus. The superiority of its biological activity over thiamine lies in its structure - a thiazole ring opens to allow easy diffusion across a membrane, then closes to become structurally active.

Benfotiamine increases transketolase activity, thereby diverting from three natural, but destructive, metabolic pathways: 1) it decreases glucose metabolites that lead to the accumulation of certain types of harmful advanced glycation end products (AGEs); 2) it normalizes protein kinase C activity; and 3) it protects the retina by preventing NF-kappaB activation in it. Research suggests that it may also protect kidneys and endothelial cells. Benfotiamine is useful for replenishing thiamine, this may be especially true in people who use the vitamin at higher levels or in those who have lifestyle habits that deplete it.

Dosage

Adults: Take 1 capsule daily with food or as directed by a healthcare professional.

Nutritional informations

Medicinal ingredients (per capsule):

Vitamin B1 (Thiamine hydrochloride) ...... 20 mg
Vitamin B2 (Riboflavin 5’-phosphate sodium) ...... 20 mg
Niacinamide ...... 130 mg
Folate (Quatrefolic® (6S)-5-methyltetrahydrofolic acid, glucosamine salt) ...... 400 mcg
Vitamin B6 (Pyridoxal 5-Phosphate) ...... 20 mg
Vitamin B12 (Methylcobalamin) ...... 400 mcg
Biotin ...... 400 mcg
Vitamin B5 (Calcium D-pantothenate) ...... 150 mg
Benfotiamine ...... 20 mg
Choline (Choline dihydrogen citrate) ...... 30 mg
Niacin ...... 10 mg

Non-medicinal ingredients: Hypromellose, stearic acid, magnesium stearate, silica.

/TABS

Adultes : Prendre 1 capsule par jour avec de la nourriture ou selon les recommandations d'un professionnel de la santé.