Berberine HCl
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Traditionally used for gastrointestinal symptoms, berberine has been shown to be a potent cardiometabolic adjuvant with varied benefits and mechanisms of action. It has hypoglycemic effects, via inhibition of alpha-glucosidase activity and an increase in insulin receptors in peripheral tissues, thereby improving insulin sensitivity. Furthermore, it activates Nrf2, a key regulator of cellular antioxidant defense, and attenuates glucose-induced neurotoxicity, suggesting therapeutic potential for diabetic neuropathy.
In controlled trials, it reduced HbA1c levels in diabetic participants with comparable effectiveness to metformin. In participants with metabolic syndrome, it was shown to reduce waist circumference and body weight, blood pressure, triglycerides, and improve insulin resistance compared to placebo, with similar benefits in participants with metabolic syndrome. women with PCOS. Berberine targets multiple cardiometabolic risk factors, as it has also been shown to reduce total cholesterol and LDL cholesterol in diabetic participants in several controlled trials. Additionally, a clinical trial comparing standard therapy with or without berberine in patients undergoing percutaneous coronary intervention showed improvements in several inflammatory markers, including C-reactive protein, IL-6, MMP-9, ICAM-1 and VCAM-1.
Adults: 1 capsule 2 times daily with meals or as recommended by a health care practitioner. Consult a health care practitioner for use beyond 3 months.
Medicinal ingredients: Berberine (hydrochloride) (Berberis vulgaris) (root) 500 mg
Nonmedicinal ingredients: Vegetable capsule (cellulose, purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica, stearic acid.
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