Three major forms of estrogen naturally present in women are estrone (E1), estradiol (E2) and estriol (E3). Hormones have important functions in every area of the body. They are chemical messengers that interact with cells throughout the body (especially in tissues that are more sensitive, including breast tissue). The most important message they give to cells is to grow, divide and multiply. This is why hormones play a crucial role in human development and tissue repair. Supporting estrogen synthesis and metabolism is essential for proper hormonal balance. It all depends on how estrogen is metabolized, different metabolites may result, each with their own biological activity. By maintaining hormone balance and ensuring that the body is able to synthesize hormones properly, I3C and DIM work together to reduce hormone overload. Current data on I3C and DIM suggest that these phytonutrients have strong potential to support breast health. I3C is a naturally occurring compound derived from cruciferous vegetables such as broccoli, Brussels sprouts and cabbage. Together, I3C and DIM promote the production of the more beneficial and protective 2-hydroxyestrone metabolite (2-OHE metabolite), rather than the production of 4-hydroxyestrone (4-OHE) and 16-alpha-hydroxyoestrone (16-alpha-OHE), metabolites that can over-stimulate cells and create free radicals that cause DNA damage. The influence of I3C and DIM on estrogen metabolism results in a more desirable ratio of 2-OHE to 16-alpha-OHE. It is this ratio that is used to assess hormonal health.
It is believed that many of the health benefits of eating cruciferous vegetables (cabbage, Brussels sprouts, broccoli, etc.) come from a group of secondary metabolites known as glucosinolates. When these vegetables are cut, crushed or chewed, the action of the enzyme myrosinase (released from the cells) hydrolyzes these glucosinolates into other compounds. For example, the glucosinolates in broccoli and cauliflower are readily converted to I3C when consumed. I3C can then be further converted by stomach acid into other health-promoting compounds, including DIM. These compounds are thought to be responsible for various cellular activities that play a role in hormonal health.
Adults: Take 1 capsule per day.
Non-medicinal ingredients: Hypromellose, stearic acid, silicon dioxide, magnesium stearate, microcrystalline cellulose, calcium silicate.
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